反应详情

1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (35 mg, 0.187 mmol), sodium acetate (19.94 mg, 0.243 mmol), and 1-(2-ammonio-1-phenylethyl)-4,4-difluoropiperidinium dichloride (51.7 mg, 0.187 mmol) were combined in 1,2-dichloroethane (2 ml). Acetic acid (0.021 ml, 0.374 mmol) and sodium triacetoxyborohydride (119 mg, 0.561 mmol) were added and the reaction stirred for 1 hour. The reaction mixture was partitioned between CH2Cl2 and satd. bicarb, the aqueous portion extracted 3×CH2Cl2, and the organic portion dried (Na2SO4) then concentrated in vacuo. The material was carried on without further purification.

1. customThe reaction mixture was partitioned between CH2Cl2 and satd
2. extractionbicarb, the aqueous portion extracted 3×CH2Cl2
3. dry with materialthe organic portion dried (Na2SO4)
4. concentrationthen concentrated in vacuo
5. customThe material was carried on without further purification