反应详情

N-(1-{[(1R)-4,9-Dioxo-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridin-1-yl]methyl}-4-methyl-4-piperidinyl)-2,2,2-trifluoroacetamide (171 mg, 0.417 mmol) was treated with a 7% solution of potassium carbonate (450 mg in 2 ml water/5 ml methanol) and stirred at rt for 2 h, and then at 70° C. for 18 h then evaporated and dissolved in 5% MeOH/DCM (100 ml), filtered and purified by SCX (5 g, eluting with MeOH and then 0.5M NH3/MeOH and then 2M NH3/MeOH). Fractions containing product were then evaporated to give product as a pink solid (60 mg, 46%)

1. customat 70° C. for 18 h then evaporated
2. dissolutiondissolved in 5% MeOH/DCM (100 ml)
3. filtrationfiltered
4. custompurified by SCX (5 g
5. washeluting with MeOH
6. additionFractions containing product
7. customwere then evaporated