反应详情

温度

100 °C

A 20 mL microwave vial was charged with, a stir bar, 3,6-dichloro-4-methylpyridazine (4.0 g, 24.54 mmol) and 14 mL of a new, freshly opened bottle of ammonium hydroxide. The vial was quickly sealed. The solution was heated in a microwave (Personal Chemistry, Emrys Optimizer) to 100° C. for 3 h. The vial was cooled, opened, and a stream of nitrogen was used to remove excess ammonium hydroxide. Water was added, the solid was collected by filtration, washed with water and dried to provide a mixture of 6-chloro-5-methylpyridazin-3-amine and 6-chloro-4-methylpyridazin-3-amine (3 g, 20.90 mmol, 85% yield). The mixture was used without further purification.

1. additionA 20 mL microwave vial was charged with, a stir bar
2. customThe vial was quickly sealed
3. temperatureThe vial was cooled
4. customto remove excess ammonium hydroxide
5. additionWater was added
6. filtrationthe solid was collected by filtration
7. washwashed with water
8. customdried
9. customto provide