6-chloro-N-(3-fluoropyridin-4-yl)-8-(1-isopropyl-1H-pyrazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamide → HCID 178456265, compound

HRID 1943469Notes

Reaction equation

HRID 1943469 reaction equation
Cl[C:2]1[CH:3]=[C:4]([NH:21][C:22]2[CH:26]=[CH:25][N:24]([CH:27]([CH3:29])[CH3:28])[N:23]=2)[C:5]2[N:6]([C:8]([C:11]([NH:13][C:14]3[CH:19]=[CH:18][N:17]=[CH:16][C:15]=3[F:20])=[O:12])=[CH:9][N:10]=2)[N:7]=1.[NH2:30][C@H:31]1[CH2:36][CH2:35][C@H:34]([OH:37])[CH2:33][CH2:32]1>CO>[F:20][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][C:14]=1[NH:13][C:11]([C:8]1[N:6]2[N:7]=[C:2]([NH:30][C@H:31]3[CH2:36][CH2:35][C@H:34]([OH:37])[CH2:33][CH2:32]3)[CH:3]=[C:4]([NH:21][C:22]3[CH:26]=[CH:25][N:24]([CH:27]([CH3:29])[CH3:28])[N:23]=3)[C:5]2=[N:10][CH:9]=1)=[O:12]

Participants

4

Reactant 2

HCID 866492696-chloro-N-(3-fluoropyridin-4-yl)-8-(1-isopropyl-1H-pyrazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamideHCID 178511715HCID 178511715, compound

Product 1

HCID 178456265HCID 178456265, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared from 48A and (trans)-4-aminocyclohexanol in a similar way as Example 44. HPLC Rt=2.850 min (Chromolith SpeedROD 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA, 4 min gradient, monitored at 220 nm), [M+1]=494.

Sources & evidence

ORD record
ord-345354ababce477eb68501b3ab1c3d84
Source dataset
uspto-grants-2013_03
Patent number
US08389527B2

Reaction notes

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