HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-N-(3-fluoropyridin-4-yl)-8-(1-isopropyl-1H-pyrazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamide → HCID 178456265, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-N-(3-fluoropyridin-4-yl)-8-(1-isopropyl-1H-pyrazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamide | HCID 86649269 | — |
| Reactant | HCID 178511715 | HCID 178511715 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178456265 | HCID 178456265 | — |
Reaction Steps
The title compound was prepared from 48A and (trans)-4-aminocyclohexanol in a similar way as Example 44. HPLC Rt=2.850 min (Chromolith SpeedROD 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA, 4 min gradient, monitored at 220 nm), [M+1]=494.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389527B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-345354ababce477eb68501b3ab1c3d84 |
| Source note | uspto-grants-2013_03 |