反应详情

3.10 g (8.73 mmol) of 2-(4′-ethyl-3-fluorobiphenyl-4-yl)-5-propenylthiophene are hydrogenated in 100 ml of THF, in the presence of Pd/C (5% of Pd) at atmospheric pressure and room temperature. The reaction solution is evaporated to dryness, and the crude product is purified by column chromatography (SiO2, n-heptane:toluene=9:1). The further purification is carried out by recrystallisation from ethanol and n-heptane, giving 2-(4′-ethyl-3-fluorobiphenyl-4-yl)-5-propylthiophene as a colourless solid (m.p. 41° C.).

1. customThe reaction solution is evaporated to dryness
2. customthe crude product is purified by column chromatography (SiO2, n-heptane:toluene=9:1)
3. customThe further purification
4. customis carried out by recrystallisation from ethanol and n-heptane