反应详情

A mixture of a mixed solvent (toluene/ethanol/water=1.5/1.5/1; 900 ml), the compound (T-2) (48.6 g, 319.6 mmol), 1-iodo-4-methoxybenzene (68.0 g, 290.6 mmol), 5% palladium on carbon (3.40 g), potassium carbonate (60.2 g, 435.9 mmol) and tetrabutylammonium bromide (23.4 g, 72.7 mmol) was refluxed with stirring for 15 hours under an atmosphere of nitrogen. The resulting reaction mixture was extracted with toluene (400 mL) three times, and the organic layers were washed with water. After the organic layer had been dried over anhydrous magnesium sulfate, the organic solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent: toluene), and then by recrystallization from a mixed solvent of heptane, methanol and ethyl acetate to give colorless crystals (57.8 g) of 3,4′-dimethoxybiphenyl (T-3).

1. customThe resulting reaction mixture
2. extractionwas extracted with toluene (400 mL) three times
3. washthe organic layers were washed with water
4. dry with materialAfter the organic layer had been dried over anhydrous magnesium sulfate
5. distillationthe organic solvent was distilled off under reduced pressure
6. customThe residue was purified by silica gel chromatography (eluent: toluene)
7. customby recrystallization from a mixed solvent of heptane, methanol and ethyl acetate