Hydrogen Bromide → HCID 131730282, compound

HRID 1943587Notes

Reaction equation

HRID 1943587 reaction equation
[OH:1][CH:2]1[CH2:5][C:4]2([CH2:10][CH2:9][N:8](C(OCC3C=CC=CC=3)=O)[CH2:7][CH2:6]2)[CH2:3]1.[BrH:21].[CH2:22]([O:24]CC)[CH3:23]>C(O)(=O)C>[BrH:21].[C:22]([O:1][CH:2]1[CH2:3][C:4]2([CH2:6][CH2:7][NH:8][CH2:9][CH2:10]2)[CH2:5]1)(=[O:24])[CH3:23]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 69670272Benzyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate

Product 1

HCID 131730282HCID 131730282, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
0 °C

Procedure

0.800 g (2.91 mmoles) of benzyl 2-hydroxy-7-aza-spiro-[3.5]nonane-7-carboxylate (WO 9222550) is slowly added to 5 ml of a 5.7N solution of hydrobromic acid in acetic acid cooled to 0° C. After stirring for 1 hr at 0° C., 50 ml of diethyl ether are added and the medium is stirred for 1 hr. The precipitate formed is filtered on a fritted filter and copiously rinsed with diethyl ether. After drying overnight under vacuum at 80° C., 0.380 g of the expected product are obtained in the form of a white solid.

Workup

  1. stirringthe medium is stirred for 1 hr
  2. customThe precipitate formed
  3. filtrationis filtered on a fritted filter
  4. washcopiously rinsed with diethyl ether
  5. customAfter drying overnight under vacuum at 80° C.

Sources & evidence

ORD record
ord-2378e71f609c4e429e3605ea25f4d937
Source dataset
uspto-grants-2013_03
Patent number
US08394787B2

Reaction notes

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