2,3-Dihydro-1H-pyrido[3,4-b][1,4]oxazine → HCID 44610275, compound

HRID 1943634Notes

Reaction equation

HRID 1943634 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][C:3]2[CH:7]=[N:8][CH:9]=[CH:10][C:2]1=2.[Br:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([Br:23])[C:20]=1[O:21][CH3:22])[C:15](Cl)=[O:16]>>[Br:11][C:12]1[CH:13]=[C:14]([C:15]([N:1]2[CH2:6][CH2:5][O:4][C:3]3[CH:7]=[N:8][CH:9]=[CH:10][C:2]2=3)=[O:16])[CH:18]=[C:19]([Br:23])[C:20]=1[O:21][CH3:22]

Participants

3

Reactant 2

HCID 219615362,3-Dihydro-1H-pyrido[3,4-b][1,4]oxazineHCID 337796303,5-Dibromo-4-methoxybenzoyl chloride

Product 1

HCID 44610275HCID 44610275, compound

Procedure

By the same method as in the step d) of Example 2, 2,3-dihydro-1H-pyrido[3,4-b][1,4]-oxazine (180 mg, 0.587 mmol) and 3,5-dibromo-4-methoxy-benzoyl chloride (193 mg, 0.587 mmol) were reacted to obtain the target compound 5, (3,5-dibromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[3,4-b][1,4]oxazin-1-yl)-methanone, as white solid (85 mg, 34%).

Sources & evidence

ORD record
ord-719ba20ef2304f3b8e9e7bd9e1b6ed85
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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