3,4-Dihydro-2,2-dimethyl-2H-pyrido[4,3-b]-1,4-oxazine → HCID 66936725, compound

HRID 1943638Notes

Reaction equation

HRID 1943638 reaction equation
[CH3:1][C:2]1([CH3:12])[O:7][C:6]2[CH:8]=[CH:9][N:10]=[CH:11][C:5]=2[NH:4][CH2:3]1.[Br:13][C:14]1[CH:15]=[C:16]([CH:20]=[C:21]([Br:25])[C:22]=1[O:23][CH3:24])[C:17](Cl)=[O:18]>>[Br:13][C:14]1[CH:15]=[C:16]([C:17]([N:4]2[CH2:3][C:2]([CH3:12])([CH3:1])[O:7][C:6]3[CH:8]=[CH:9][N:10]=[CH:11][C:5]2=3)=[O:18])[CH:20]=[C:21]([Br:25])[C:22]=1[O:23][CH3:24]

Participants

3

Reactant 2

HCID 158572103,4-Dihydro-2,2-dimethyl-2H-pyrido[4,3-b]-1,4-oxazineHCID 337796303,5-Dibromo-4-methoxybenzoyl chloride

Product 1

HCID 66936725HCID 66936725, compoundYield 44.5%

Procedure

By the same method as in the step d) of Example 2, 2,2-dimethyl-3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine (60 mg, 0.36 mmol) was reacted with 3,5-dibromo-4-methoxy-benzoyl chloride (120 mg, 0.36 mmol) to obtain the target compound, (3,5-dibromo-4-methoxy-phenyl)-(2,2-dimethyl-2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (73 mg, 44%).

Sources & evidence

ORD record
ord-352561afba39490d901ea3800ba77857
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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