HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → (3-Bromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3-Bromo-4-methoxybenzoic acid | HCID 66836 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2H,3H,4H-pyrido[4,3-b][1,4]oxazine | HCID 21885950 | — |
| Product | (3-Bromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone | HCID 66936511 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a mixture of 3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine (50 mg, 0.37 mmol) and 3-bromo-4-methoxy-benzoic acid (102 mg, 0.44 mmol), phosphorus oxychloride (2 ml) was added and stirred at 100° C. for 12 hours. The reaction mixture was cooled to 0° C., neutralized with saturated solution of sodium hydrogen carbonate to pH of 8-9 and extracted with ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394792B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-29afa628e925493d956bef5c02e2ffdd |
| Source note | uspto-grants-2013_03 |