反应详情

To phosphorus oxychloride (3.00 ml), 3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine (177 mg, 1.30 mmol) and 3-chloro-4-methoxy-5-nitro benzoic acid (200 mg, 0.87 mmol) were added and then stirred at 95□ for 16 hours. After completion of the reaction, the reaction mixture was poured into ice water and neutralized with saturated solution of sodium hydroxide, and extracted with ethyl acetate. The combined organic layer was dried over anhydrous sodium sulfate

1. customAfter completion of the reaction
2. extractionextracted with ethyl acetate
3. dry with materialThe combined organic layer was dried over anhydrous sodium sulfate