Boron tribromide → HCID 44610443, compound

HRID 1943649Notes

Reaction equation

HRID 1943649 reaction equation
[N:1]1([C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[C:15]([C:21]([F:24])([F:23])[F:22])[CH:14]=2)=[O:12])[CH2:6][CH2:5][O:4][C:3]2[CH:7]=[N:8][CH:9]=[CH:10][C:2]1=2.B(Br)(Br)Br>>[N:1]1([C:11]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([C:21]([F:24])([F:22])[F:23])[CH:14]=2)=[O:12])[CH2:6][CH2:5][O:4][C:3]2[CH:7]=[N:8][CH:9]=[CH:10][C:2]1=2

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 66936848HCID 66936848, compound

Product 1

HCID 44610443HCID 44610443, compound

Procedure

By the same method as in the step b) of Example 12, (2,3-dihydro-pyrido[3,4-b][1,4]oxazin-1-yl)-(4-methoxy-3-trifluoromethyl-phenyl)-methanone (110 mg, 0.325 mmol) was reacted with 1M solution of boron tribromide (3.25 ml, 3.25 mmol) to obtain the target compound, (2,3-dihydro-pyrido[3,4-b][1,4]oxazin-1-yl)-(4-hydroxy-3-trifluoromethyl-phenyl)-methanone, as white solid (11 mg, 10%).

Sources & evidence

ORD record
ord-ab9582c3b27a424bb2c05f2eae994f81
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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