Boron tribromide → HCID 44608382, compound

HRID 1943684Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([C:10]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[CH:18]=[N:19][CH:20]=[CH:21][C:13]2=3)=[O:11])[CH:5]=[CH:6][C:7]=1[O:8]C.B(Br)(Br)Br>>[Br:1][C:2]1[CH:3]=[C:4]([C:10]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[CH:18]=[N:19][CH:20]=[CH:21][C:13]2=3)=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 66936925HCID 66936925, compound

Product 1

HCID 44608382HCID 44608382, compound

Procedure

By the same method as in Example 3, (3-bromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[3,4-b][1,4]oxazin-1-yl)-methanone (200 mg, 0.58 mmol) and 1M solution of boron tribromide (2.9 ml, 2.9 mmol)) were reacted to obtain the target compound 40, i.e., (3-bromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[3,4-b][1,4]oxazin-1-yl)-methanone, as beige solid (95 mg, 49%).

Sources & evidence

ORD record: ord-0a7df8bd632a46f7b327cc73db70feed
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394792B2

Reaction notes

Loading…