3-Nitrophenylboronic Acid → HCID 66936363, compound

Participants

Reaction Steps

By the same method as in the step b) of Example 45, 7-bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine (99 mg, 0.46 mmol), 3-nitrophenyl boronic acid (115 mg, 0.69 mmol), palladium triphenylphosphine (26 mg, 0.023 mol) and potassium carbonate (127 mg, 0.92 mmol) were dissolved in tetrahydrofuran/water (2.4 ml/0.4 ml) and then stirred at 80□ for 6 hours to obtain 7-(3-nitro-phenyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine as white solid (90.4 mg, 76%).

Provenance & Evidence