HCID 178526762, compound → HCID 178507989, compound

HRID 1943711Notes

Reaction equation

HRID 1943711 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[OH:14])=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[OH:14])=[CH:11][CH:10]=[CH:9][CH:8]=2

Participants

4

Reactant 1

HCID 178526762HCID 178526762, compound

Product 1

HCID 178507989HCID 178507989, compoundYield 105.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a 100 ml flask, 3-nitro-quinolin-4-ol (500 mg, 2.629 mmol) was dissolved in methanol (50 ml) and 10% palladium on active carbon (1.2 g, 10 w/w %) was added thereto and then stirred for 3 hours at room temperature under hydrogen atmosphere. The reaction mixture was filtered on celite and then evaporated under reduced pressure to obtain brown liquid (445 mg, quantitative yield).

Workup

  1. filtrationThe reaction mixture was filtered on celite
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-d17fb2e84280475e91c8551abfda31fe
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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