Potassium Carbonate → HCID 178519776, compound

HRID 1943720Notes

Reaction equation

HRID 1943720 reaction equation
[OH:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[C:4]([OH:11])[N:3]=1.S(Cl)(Cl)=O.C(=O)([O-])[O-].[K+].[K+].[O:22]1[CH2:27][CH2:26][NH:25][C:24]2[CH:28]=[N:29][CH:30]=[CH:31][C:23]1=2>>[O:22]1[CH2:27][CH2:26][N:25]([C:8]([C:6]2[CH:5]=[C:4]([OH:11])[N:3]=[C:2]([OH:1])[N:7]=2)=[O:10])[C:24]2[CH:28]=[N:29][CH:30]=[CH:31][C:23]1=2

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 24386Thionyl ChlorideHCID 218859502H,3H,4H-pyrido[4,3-b][1,4]oxazineHCID 178524638HCID 178524638, compound

Product 1

HCID 178519776HCID 178519776, compound

Procedure

By the same method as in Example 59, 2,6-dihydroxy-pyrimidin-4-carboxylic acid (125 mg, 0.80 mmol), thionyl chloride (0.066 ml, 0.90 mmol), potassium carbonate (138 mg, 1.0 mmol) and 3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine (109 mg, 0.80 mmol) were reacted and the reaction mixture was purified in the same manner to obtain the target compound 60, i.e., (2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-(2,6-dihydroxy-pyrimidin-4-yl)-methanone, as white solid (32 mg, 15%).

Workup

  1. customthe reaction mixture was purified in the same manner

Sources & evidence

ORD record
ord-6b369d67f735461bbbd1274ad5424837
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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