Sodium Hydroxide → HCID 66936406, compound

HRID 1943744Notes

Reaction equation

HRID 1943744 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:10]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[CH:18]=[CH:19][N:20]=[CH:21][C:13]2=3)=[O:11])[CH:5]=[C:6]([Br:9])[C:7]=1[OH:8].[OH-].[Na+:23]>O1CCCC1>[Na+:23].[Br:9][C:6]1[CH:5]=[C:4]([C:10]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[CH:18]=[CH:19][N:20]=[CH:21][C:13]2=3)=[O:11])[CH:3]=[C:2]([Br:1])[C:7]=1[O-:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 44608229Epaminurad

Product 1

HCID 66936406HCID 66936406, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a 100 ml flask, (3,5-dibromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (500 mg, 1.20 mmol) was suspended in tetrahydrofuran (40 ml) and the mixture was dissolved under heating. After cooling to room temperature, 10N sodium hydroxide solution was added thereto dropwise. The solvent was evaporated under reduced pressure, and the residue was dissolved in a solvent of acetonitrile and water (1:1 ratio, 80 ml) to obtain the target compound 72 as white non-crystalline form (240 mg, 48%).

Workup

  1. dissolutionthe mixture was dissolved
  2. temperatureunder heating
  3. customThe solvent was evaporated under reduced pressure
  4. dissolutionthe residue was dissolved in a solvent of acetonitrile and water (1:1 ratio, 80 ml)

Sources & evidence

ORD record
ord-b72690a4dd434e23bb961cca8ff6f4d1
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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