反应详情

In a 100 ml flask, (3,5-dibromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (500 mg, 1.20 mmol) was suspended in tetrahydrofuran (40 ml) and the mixture was dissolved under heating. After cooling to room temperature, 10N sodium hydroxide solution was added thereto dropwise. The solvent was evaporated under reduced pressure, and the residue was dissolved in a solvent of acetonitrile and water (1:1 ratio, 80 ml) to obtain the target compound 72 as white non-crystalline form (240 mg, 48%).

1. dissolutionthe mixture was dissolved
2. temperatureunder heating
3. customThe solvent was evaporated under reduced pressure
4. dissolutionthe residue was dissolved in a solvent of acetonitrile and water (1:1 ratio, 80 ml)