反应详情

In a 100 ml flask, (3,5-dibromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (500 mg, 1.20 mmol) was suspended in tetrahydrofuran (40 ml) and the mixture was dissolved under heating. After cooling to room temperature, 10N potassium hydroxide solution was added thereto dropwise. The solvent was evaporated under reduced pressure, and the residue was dissolved in a solvent of acetonitrile and water (1:1 ratio, 80 ml), and freeze-dried to obtain the target compound 73 as white non-crystalline form (480 mg, 92%).

1. dissolutionthe mixture was dissolved
2. temperatureunder heating
3. customThe solvent was evaporated under reduced pressure
4. dissolutionthe residue was dissolved in a solvent of acetonitrile and water (1:1 ratio, 80 ml)
5. customfreeze-dried