Potassium Hydroxide → HCID 44609196, compound

HRID 1943745Notes

Reaction equation

HRID 1943745 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:10]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[CH:18]=[CH:19][N:20]=[CH:21][C:13]2=3)=[O:11])[CH:5]=[C:6]([Br:9])[C:7]=1[OH:8].[OH-].[K+:23]>O1CCCC1>[K+:23].[Br:9][C:6]1[CH:5]=[C:4]([C:10]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[CH:18]=[CH:19][N:20]=[CH:21][C:13]2=3)=[O:11])[CH:3]=[C:2]([Br:1])[C:7]=1[O-:8]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 44608229Epaminurad

Product 1

HCID 44609196HCID 44609196, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a 100 ml flask, (3,5-dibromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (500 mg, 1.20 mmol) was suspended in tetrahydrofuran (40 ml) and the mixture was dissolved under heating. After cooling to room temperature, 10N potassium hydroxide solution was added thereto dropwise. The solvent was evaporated under reduced pressure, and the residue was dissolved in a solvent of acetonitrile and water (1:1 ratio, 80 ml), and freeze-dried to obtain the target compound 73 as white non-crystalline form (480 mg, 92%).

Workup

  1. dissolutionthe mixture was dissolved
  2. temperatureunder heating
  3. customThe solvent was evaporated under reduced pressure
  4. dissolutionthe residue was dissolved in a solvent of acetonitrile and water (1:1 ratio, 80 ml)
  5. customfreeze-dried

Sources & evidence

ORD record
ord-e56cb382b8de40ff8e24e6dd9d5cb01e
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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