Acetyl chloride → HCID 58853262, compound

HRID 1943775Notes

Reaction equation

HRID 1943775 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:12][C:13]2[CH:18]=[N:17][CH:16]=[C:15]([Cl:19])[N:14]=2)[CH2:9][CH2:10][CH3:11])[CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[C:27](Cl)(=[O:29])[CH3:28]>ClCCl>[Cl:19][C:15]1[N:14]=[C:13]([NH:12][CH:8]([C:4]2[CH:3]=[C:2]([NH:1][C:27](=[O:29])[CH3:28])[CH:7]=[CH:6][CH:5]=2)[CH2:9][CH2:10][CH3:11])[CH:18]=[N:17][CH:16]=1

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 58853217HCID 58853217, compound

Product 1

HCID 58853262HCID 58853262, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred solution of N-[1-(3-aminophenyl)butyl]-6-chloropyrazin-2-amine (0.10 g, 0.36 mmol) and triethylamine (100 μl, O.72 mmol) in dichloromethane (3 mL) cooled to 0° C. was added acetyl chloride (31 μL, 0.43 mmol). The resulting mixture was stirred at room temperature for 18 h. then diluted with dichloromethane (10 mL) and washed with H2O (10 mL) and brine (10 mL). The organic phase was collected, dried and concentrated and the residue purified by flash chromatography eluting with ethyl acetate-hexane (1:1) to give pure product (94 mg, 82%).

Workup

  1. washwashed with H2O (10 mL) and brine (10 mL)
  2. customThe organic phase was collected
  3. customdried
  4. concentrationconcentrated
  5. customthe residue purified by flash chromatography
  6. washeluting with ethyl acetate-hexane (1:1)

Sources & evidence

ORD record
ord-ff520a04f1e8439b8c112ed6f1007801
Source dataset
uspto-grants-2013_03
Patent number
US08394806B2

Reaction notes

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