HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1943873Generated: November 1, 2026
Hydrazine hydrate (1:1) → HCID 178451767, compound
https://huagongshe.com/reaction/1943873
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Tert-butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate | HCID 22265410 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178451767 | HCID 178451767 | — |
Reaction Steps
A 5 mL conical reaction vial was charged with tert-butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate (348 mg, 1.379 mmol), hydrazine monohydrate (329.4 μL, 6.896 mmol) and EtOH (4 mL). The reaction vessel was sealed and heated to 80° C. for 20 hours. The volatiles were removed to afford tert-butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate as a foam (367 mg. 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08394795B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-0462e403d217419d99a128bba3f0bed4 |
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| Source note | uspto-grants-2013_03 |
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