Hydrochloric Acid → HCID 178479167, compound

HRID 1943898Notes

Reaction equation

HRID 1943898 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:12]([NH:13]C(=O)C)=[N:11][NH:10][C:7]2=[N:8][CH:9]=1)([O-:3])=[O:2].[ClH:17]>CCO>[ClH:17].[N+:1]([C:4]1[CH:5]=[C:6]2[C:12]([NH2:13])=[N:11][NH:10][C:7]2=[N:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178474499HCID 178474499, compound

Product 1

HCID 178479167HCID 178479167, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of N-(5-nitro-1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide (530 mg, 2.40 mmol), EtOH (2.4 mL, 1M) and concentrated HCl (37%) (2.5 mL, 68.6 mmol) was heated to 85° C. for 3 hours. The volatiles were removed to afford 5-nitro-1H-pyrazolo[3,4-b]pyridin-3-amine hydrochloride (500 mg, 97% yield) as a solid.

Workup

  1. customThe volatiles were removed

Sources & evidence

ORD record
ord-589e8d80da314582aa7b6e091cfb3f17
Source dataset
uspto-grants-2013_03
Patent number
US08394795B2

Reaction notes

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