反应详情

5-Nitro-1H-pyrazolo[3,4-b]pyridin-3-amine hydrochloride was suspended in EtOAc (300 mL) and water (100 mL). The mixture was treated with a 2M solution of NaOH (1027 μL, 2.05 mmol). The organic layer was separated, washed with water (2×50 mL) and brine (50 mL), dried (Na2SO4), filtered and concentrated to afford 5-nitro-1H-pyrazolo[3,4-b]pyridin-3-amine (275 mg, 75% yield) as a solid.

1. customThe organic layer was separated
2. washwashed with water (2×50 mL) and brine (50 mL)
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated