HRID1944009

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66144

Propanoic acid, 3-bromo-2-oxo-, ethyl ester

C5H7BrO3

结构：Nc1cc(NC(=O)c2cc3cc(C(F)(F)F)ccc3n2Cc2cccc(F)c2)ccn1

HCID66863244

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cn2ccc(NC(=O)c3cc4cc(C(F)(F)F)ccc4n3Cc3cccc(F)c3)cc2n1

HCID66863389

未命名化合物

收率 67.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

The compound is prepared according to a process similar to that described in step 15.3, by reacting 0.23 g (0.54 mmol) of N-[2-aminopyrid-4-yl]-5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide, prepared according to the protocol described in step 17.2, with 0.21 g (1.07 mmol) of ethyl 3-bromo-2-oxopropionate in 4 mL of acetonitrile. 192 mg of the expected product are obtained.

WORKUP

后处理

customThe compound is prepared
customprepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-756d8ed3f4d64b999dae7fc919a17482
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394820B2
来源说明: uspto-grants-2013_03

反应 SMILES

[NH2:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[N:12]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[CH:26]=3)[C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=3)=[O:10])[CH:5]=[CH:4][N:3]=1.Br[CH2:33][C:34](=O)[C:35]([O:37][CH2:38][CH3:39])=[O:36]>C(#N)C>[CH2:38]([O:37][C:35]([C:34]1[N:1]=[C:2]2[CH:7]=[C:6]([NH:8][C:9]([C:11]3[N:12]([CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[CH:26]=4)[C:13]4[C:18]([CH:19]=3)=[CH:17][C:16]([C:20]([F:23])([F:21])[F:22])=[CH:15][CH:14]=4)=[O:10])[CH:5]=[CH:4][N:3]2[CH:33]=1)=[O:36])[CH3:39]