HRID1944012

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21226445

未命名化合物

结构：CCOC(=O)c1cn2ccc(NC(=O)c3cc4cc(C(F)(F)F)cnc4n3Cc3cccc(F)c3)cc2n1

HCID66863391

未命名化合物

PRODUCTS

生成物

HCID66863391

未命名化合物

结构：O=C(Nc1ccn2cc(CO)nc2c1)c1cc2cc(C(F)(F)F)cnc2n1Cc1cccc(F)c1

HCID66863469

未命名化合物

收率 36.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Compound 18 was prepared according to a process similar to that described in step 17.4, by reacting 0.13 g (0.25 mmol) of N-[2-(ethyloxycarbonyl)imidazo[1,2-a]pyrid-7-yl]-5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide, prepared according to the protocol described in step 18.1, with 0.32 mL of a molar solution of LiAlH4 in 4 mL of tetrahydrofuran. 22 mg of the expected product are obtained.

WORKUP

后处理

customprepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-219e5868d12f40ba95184c5e8727ab63
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394820B2
来源说明: uspto-grants-2013_03

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]2[CH:13]=[C:12]([NH:14][C:15]([C:17]3[N:29]([CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[CH:32]=4)[C:20]4=[N:21][CH:22]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:24]=[C:19]4[CH:18]=3)=[O:16])[CH:11]=[CH:10][N:9]2[CH:38]=1)=[O:5])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>O1CCCC1>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]2[CH:13]=[C:12]([NH:14][C:15]([C:17]3[N:29]([CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[CH:32]=4)[C:20]4=[N:21][CH:22]=[C:23]([C:25]([F:27])([F:26])[F:28])[CH:24]=[C:19]4[CH:18]=3)=[O:16])[CH:11]=[CH:10][N:9]2[CH:38]=1)=[O:5])[CH3:2].[OH:3][CH2:4][C:6]1[N:7]=[C:8]2[CH:13]=[C:12]([NH:14][C:15]([C:17]3[N:29]([CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[CH:32]=4)[C:20]4=[N:21][CH:22]=[C:23]([C:25]([F:26])([F:28])[F:27])[CH:24]=[C:19]4[CH:18]=3)=[O:16])[CH:11]=[CH:10][N:9]2[CH:38]=1