反应详情

温度

77 °C

To EtOH (27.8 L), triethyl orthoformate (9.26 L, 55.6 mol) and diethyl 4-oxopimelate (5.93 L, 27.8 mol) was added p-toluenesulfonic acid monohydrate (0.053 kg, 0.278 mol), and the reaction mixture was heated to 77.0° C. with stirring for 20 h. Heating was discontinued, and ethanol was removed by distillation under vacuum, starting with the batch at 63° C. The remaining orange ketal solution was dissolved in toluene (32 L) and transferred to a 100-L extractor that had been charged with 2% NaHCO3 (24 L), with stirring.

1. temperatureHeating
2. customethanol was removed by distillation under vacuum
3. customstarting with the batch at 63° C
4. dissolutionThe remaining orange ketal solution was dissolved in toluene (32 L)
5. additionhad been charged with 2% NaHCO3 (24 L)
6. stirringwith stirring