Cyclobutanecarbonyl chloride → HCID 66925793, compound

HRID 1944113Notes

Reaction equation

HRID 1944113 reaction equation
[C:1]([O:5][C:6](=[O:14])[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH:15]1([C:19](Cl)=[O:20])[CH2:18][CH2:17][CH2:16]1>>[C:1]([O:5][C:6](=[O:14])[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:19]([CH:15]2[CH2:18][CH2:17][CH2:16]2)=[O:20])[CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 78705Cyclobutanecarbonyl chlorideHCID 1514172(3R)-3-Aminopiperidine, 3-BOC protected

Product 1

HCID 66925793HCID 66925793, compound

Procedure

Acylation of (R)-piperidin-3-yl-carbamic acid tert-butyl ester (300 mg) with cyclobutyl carbonylchloride (0.342 ml) was performed according to the method described for example 20c. The residue was concentrated in vacuo and used in the next step without purification.

Workup

  1. concentrationThe residue was concentrated in vacuo
  2. customused in the next step without purification

Sources & evidence

ORD record
ord-493d1c6d26e14848a45f4fd8bd63d86e
Source dataset
uspto-grants-2013_03
Patent number
US08394789B2

Reaction notes

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