反应详情

To methyl 2-(4-(hydroxymethyl)phenyl)acetate (E132) in CH2Cl2 at 0° C. was added 2,6-lutidine and TIPS-OTf. The ice bath was removed and the solution was allowed to warm to room temperature and stir. After 4 h the solution was poured into NH4Cl(sat) and CH2Cl2 and the organic layer was further extracted with NH4Cl(sat). The organics were dried (MgSO4) filtered and evaporated. Column chromatography (SiO2, 0-15% EtOAc/Hexanes) gave pure methyl 2-(4-((triisopropylsilyloxy)methyl)phenyl)acetate (E133).

1. customThe ice bath was removed
2. additionAfter 4 h the solution was poured into NH4Cl(sat) and CH2Cl2
3. extractionthe organic layer was further extracted with NH4Cl(sat)
4. dry with materialThe organics were dried (MgSO4)
5. filtrationfiltered
6. customevaporated