Hydrochloric Acid → 4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl cyclohexanecarboxylate dihydrochloride

HRID 1944140Notes

Reaction equation

HRID 1944140 reaction equation
[CH:1]1([C:7]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]([CH2:31][NH:32]C(OC(C)(C)C)=O)[C:18]([NH:20][C:21]3[CH:22]=[C:23]4[C:28](=[CH:29][CH:30]=3)[CH:27]=[N:26][CH:25]=[CH:24]4)=[O:19])=[CH:13][CH:12]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:40]>C(Cl)Cl>[ClH:40].[ClH:40].[CH:1]1([C:7]([O:9][CH2:10][C:11]2[CH:12]=[CH:13][C:14]([CH:17]([CH2:31][NH2:32])[C:18]([NH:20][C:21]3[CH:22]=[C:23]4[C:28](=[CH:29][CH:30]=3)[CH:27]=[N:26][CH:25]=[CH:24]4)=[O:19])=[CH:15][CH:16]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59563743HCID 59563743, compound

Product 1

HCID 666002034-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl cyclohexanecarboxylate dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 4-(3-(tert-butoxycarbonylamino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl cyclohexanecarboxylate (E142) in CH2Cl2 was added HCl (4 N in dioxane) and the solution was stirred for 8-10 h. The solvents were evaporated to give pure 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl cyclohexanecarboxylate dihydrochloride (E143).

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-f94edc0589304e42aac86a1eb63e4961
Source dataset
uspto-grants-2013_03
Patent number
US08394826B2

Reaction notes

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