Hydrochloric Acid → HCID 66599495, compound

HRID 1944164Notes

Reaction equation

HRID 1944164 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:39])[CH:13]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31](=[O:38])[C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)=[CH:25][CH:24]=3)[CH2:14][NH:15]C(=O)OC(C)(C)C)=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[ClH:40]>C(Cl)Cl>[ClH:40].[ClH:40].[NH2:15][CH2:14][CH:13]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31](=[O:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:25][CH:24]=1)[C:12]([NH:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:1]=[N:2][CH:3]=[CH:4]2)=[O:39]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59563707HCID 59563707, compound

Product 1

HCID 66599495HCID 66599495, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(2-oxo-2-phenylethoxy)phenyl)propylcarbamate (E275) in CH2Cl2 was added HCl (4 N, dioxane) and the solution was stirred overnight. The solvents were evaporated to give pure 3-amino-N-(isoquinolin-6-yl)-2-(4-(2-oxo-2-phenylethoxy)phenyl)propanamide dihydrochloride (E277).

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-6ba36f2faac4478c9d630a010f7e277e
Source dataset
uspto-grants-2013_03
Patent number
US08394826B2

Reaction notes

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