HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1944168Generated: November 2, 2026
Hydroxyphenylacetic acid → Benzyl 2-(4-hydroxyphenyl)acetate
https://huagongshe.com/reaction/1944168
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyphenylacetic acid | HCID 127 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzyl 2-(4-hydroxyphenyl)acetate | HCID 11107524 | — |
Reaction Steps
To 2-(4-hydroxyphenyl)acetic acid in DMF cooled to 0° C. was added K2CO3 and the solution was stirred for 30 min. Then, benzyl bromide was added and the solution stirred at 0° C. and was allowed to slowly warm to 15-20° C. After all the ice was melted the solution was poured into NH4Cl(sat) and extracted with EtOAc. The combined organics were dried (Na2SO4), filtered, and evaporated. Column chromatography (SiO2, 0-35% EtOAc/Hex) gave pure benzyl 2-(4-hydroxyphenyl)acetate (E301).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08394826B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-dc6536b643ab431b8279947673fbfe18 |
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| Source note | uspto-grants-2013_03 |
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