Hydrochloric Acid → HCID 66599798, compound

HRID 1944172Notes

Reaction equation

HRID 1944172 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]([NH:21][C:22]2[CH:23]=[C:24]3[C:29](=[CH:30][CH:31]=2)[CH:28]=[N:27][CH:26]=[CH:25]3)=[O:20])[CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.[ClH:32]>C(Cl)Cl.O>[ClH:32].[ClH:32].[NH2:11][CH2:10][CH2:9][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1)[C:19]([NH:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[CH:28]=[N:27][CH:26]=[CH:25]2)=[O:20]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59563761HCID 59563761, compound

Product 1

HCID 66599798HCID 66599798, compound

Reagents, catalysts & solvents 2

HCID 962WaterCatalystHCID 6344DichloromethaneSolvent

Procedure

To tert-butyl 3-(4-hydroxyphenyl)-4-(isoquinolin-6-ylamino)-4-oxobutylcarbamate (E307) in CH2Cl2 was added HCl (4 N in dioxane) and 2 drops of H2O and the solution was stirred overnight at room temperature. The solvents were evaporated to give 4-amino-2-(4-hydroxyphenyl)-N-(isoquinolin-6-yl)butanamide dihydrochloride (E308).

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-aa8a815fa0c1407eb32ccc8e15a9fa08
Source dataset
uspto-grants-2013_03
Patent number
US08394826B2

Reaction notes

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