2-Fluoro-4-nitrobenzamide → 4-Amino-2-fluoro-benzamide

HRID 1944177Notes

Reaction equation

HRID 1944177 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]>CCO.[Pd]>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([F:1])[CH:10]=1

Participants

4

Reactant 1

HCID 217840942-Fluoro-4-nitrobenzamide

Product 1

HCID 230680054-Amino-2-fluoro-benzamide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 23938PalladiumSolvent

Procedure

2-fluoro-4-nitrobenzamide (E335) was dissolved in EtOH under Ar and 10% Pd/C added. The reaction was pump-purged with H2 and left stirring at room temperature overnight. The catalyst was removed by filtration and the reaction concentrated to give pure 4-amino-2-fluorobenzamide (E336).

Workup

  1. additionadded
  2. customThe reaction was pump-purged with H2
  3. waitleft
  4. customThe catalyst was removed by filtration
  5. concentrationthe reaction concentrated

Sources & evidence

ORD record
ord-ff1e2b95a72d4361b847f2e368d3c0c1
Source dataset
uspto-grants-2013_03
Patent number
US08394826B2

Reaction notes

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