Dichloromethane → 5-bromo-N-(3-chloro-4-morpholinophenyl)-8-(piperidine-4-yloxy) quinazolin-2-amine

HRID 194429Notes

Reaction equation

HRID 194429 reaction equation
[Br:1][c:2]1[c:3]2[cH:4][n:5][c:6]([NH:26][c:27]3[cH:28][c:29]([Cl:39])[c:30]([N:33]4[CH2:34][CH2:35][O:36][CH2:37][CH2:38]4)[cH:31][cH:32]3)[n:7][c:8]2[c:9]([O:12][CH:13]2[CH2:14][CH2:15][N:16]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:17][CH2:18]2)[cH:10][cH:11]1.[Cl:47][CH2:48][Cl:49].[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46]>>[Br:1][c:2]1[c:3]2[cH:4][n:5][c:6]([NH:26][c:27]3[cH:28][c:29]([Cl:39])[c:30]([N:33]4[CH2:34][CH2:35][O:36][CH2:37][CH2:38]4)[cH:31][cH:32]3)[n:7][c:8]2[c:9]([O:12][CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[cH:10][cH:11]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59199220Tert-butyl 4-(5-bromo-2-(3-chloro-4-morpholinophenylamino) quinazolin-8-yloxy)piperidine-1-carboxylate

Product 1

HCID 671022375-bromo-N-(3-chloro-4-morpholinophenyl)-8-(piperidine-4-yloxy) quinazolin-2-amine

Sources & evidence

ORD record
ord-d8417f65190042249862b2aefb406662
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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