反应详情

温度

60 °C

A solution of (4-chloro-3-nitrophenoxy)acetic acid methyl ester (30 g) in methanol (100 mL) was added to a mixture of iron (26 g), ammonium chloride (33 g) and water (400 mL) at room temperature, and the resulting mixture was heated in an ultrasonic bath at 60° C. for 4 hours. The mixture was basified by the addition of sodium hydroxide, extracted with ethyl acetate, and the combined extracts were washed with 1.0M aqueous hydrochloric acid solution. The pH of the combined aqueous phases was adjusted to 7-8 by the addition of sodium hydroxide, and the resulting precipitate was collected by filtration and then dried to afford title compound (14 g).

1. extractionextracted with ethyl acetate
2. washthe combined extracts were washed with 1.0M aqueous hydrochloric acid solution
3. additionThe pH of the combined aqueous phases was adjusted to 7-8 by the addition of sodium hydroxide
4. filtrationthe resulting precipitate was collected by filtration
5. customdried