Chlorodifluoromethane → HCID 67455340, compound

HRID 1944312Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:31])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]2[C:7]=1[C:8]([CH3:30])=[C:9]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]3[CH:29]=[CH:28][CH:27]=[N:26]3)=[CH:21][CH:20]=1)[C:10](=[O:17])[NH:11]2.Cl[CH:33]([F:35])[F:34]>>[CH3:1][O:2][C:3](=[O:31])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]2[C:7]=1[C:8]([CH3:30])=[C:9]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]3[CH:29]=[CH:28][CH:27]=[N:26]3)=[CH:21][CH:20]=1)[C:10]([O:17][CH:33]([F:35])[F:34])=[N:11]2

Participants

Reactant 2

HCID 6372Chlorodifluoromethane

HCID 67456764HCID 67456764, compound

Product 1

HCID 67455340HCID 67455340, compound

Procedure

The title compound was prepared by the method of Preparation 10c using [8-fluoro-4-methyl-2-oxo-3-(4-pyrazol-1-ylbenzyl)-1,2-dihydroquinolin-5-yloxy]acetic acid methyl ester and chlorodifluoromethane.

Sources & evidence

ORD record: ord-5cb2c9bd617348698d2c81b9daad16d1
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394830B2

Reaction notes

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