Methyl 2-(3-amino-4-chlorophenoxy)acetate → [8-Chloro-2-ethyl-3-(4-isobutyrylbenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester

HRID 1944317Notes

Reaction equation

HRID 1944317 reaction equation
[CH3:1][O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([NH2:13])[CH:7]=1.C([O:17][C:18](=O)[CH:19]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31](=[O:35])[CH:32]([CH3:34])[CH3:33])=[CH:27][CH:26]=1)[C:20](=O)[CH2:21][CH3:22])C>>[CH3:1][O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]2[C:7]=1[C:18](=[O:17])[C:19]([CH2:24][C:25]1[CH:26]=[CH:27][C:28]([C:31](=[O:35])[CH:32]([CH3:33])[CH3:34])=[CH:29][CH:30]=1)=[C:20]([CH2:21][CH3:22])[NH:13]2

Participants

3

Reactant 2

HCID 66717604Methyl 2-(3-amino-4-chlorophenoxy)acetateHCID 674582902-(4-Isobutyrylbenzyl)-3-oxopentanoic acid ethyl ester

Product 1

HCID 67456772[8-Chloro-2-ethyl-3-(4-isobutyrylbenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester

Procedure

The title compound was prepared by the method of Preparation 1c using (3-amino-4-chlorophenoxy)acetic acid methyl ester and 2-(4-isobutyrylbenzyl)-3-oxopentanoic acid ethyl ester.

Sources & evidence

ORD record
ord-0b4be07a8035409a95f6b19a139bc684
Source dataset
uspto-grants-2013_03
Patent number
US08394830B2

Reaction notes

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