1H-Imidazole, 2-(1-methylethyl)- → {4-Difluoromethoxy-2-ethyl-8-fluoro-3-[4-(2-isopropylimidazol-1-yl)benzyl]quinolin-5-yloxy}acetic acid methyl ester

HRID 1944340Notes

Reaction equation

HRID 1944340 reaction equation
[F:1][CH:2]([F:33])[O:3][C:4]1[C:13]2[C:8](=[C:9]([F:20])[CH:10]=[CH:11][C:12]=2[O:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[N:7]=[C:6]([CH2:21][CH3:22])[C:5]=1[CH2:23][C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1.[CH:34]([C:37]1[NH:38][CH:39]=[CH:40][N:41]=1)([CH3:36])[CH3:35]>>[CH3:19][O:18][C:16](=[O:17])[CH2:15][O:14][C:12]1[CH:11]=[CH:10][C:9]([F:20])=[C:8]2[C:13]=1[C:4]([O:3][CH:2]([F:33])[F:1])=[C:5]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([N:38]3[CH:39]=[CH:40][N:41]=[C:37]3[CH:34]([CH3:36])[CH3:35])=[CH:26][CH:25]=1)[C:6]([CH2:21][CH3:22])=[N:7]2

Participants

3

Reactant 2

HCID 1234571H-Imidazole, 2-(1-methylethyl)-HCID 67458287(4-{[4-Difluoromethoxy-2-ethyl-8-fluoro-5-(2-methoxy-2-oxoethoxy) quinolin-3-yl]methyl}phenyl)boronic acid

Product 1

HCID 67458497{4-Difluoromethoxy-2-ethyl-8-fluoro-3-[4-(2-isopropylimidazol-1-yl)benzyl]quinolin-5-yloxy}acetic acid methyl ester

Procedure

The title compound was prepared by the method of Preparation 23b using (4-{[4-difluoromethoxy-2-ethyl-8-fluoro-5-(2-methoxy-2-oxoethoxy)quinolin-3-yl]methyl}phenyl)boronic acid and 2-isopropyl-1H-imidazole.

Sources & evidence

ORD record
ord-f0774daaab8646e985deab1eda6786df
Source dataset
uspto-grants-2013_03
Patent number
US08394830B2

Reaction notes

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