HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Imidazole, 2-(1-methylethyl)- → {4-Difluoromethoxy-2-ethyl-8-fluoro-3-[4-(2-isopropylimidazol-1-yl)benzyl]quinolin-5-yloxy}acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Imidazole, 2-(1-methylethyl)- | HCID 123457 | — |
| Reactant | (4-{[4-Difluoromethoxy-2-ethyl-8-fluoro-5-(2-methoxy-2-oxoethoxy) quinolin-3-yl]methyl}phenyl)boronic acid | HCID 67458287 | — |
| Product | {4-Difluoromethoxy-2-ethyl-8-fluoro-3-[4-(2-isopropylimidazol-1-yl)benzyl]quinolin-5-yloxy}acetic acid methyl ester | HCID 67458497 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 23b using (4-{[4-difluoromethoxy-2-ethyl-8-fluoro-5-(2-methoxy-2-oxoethoxy)quinolin-3-yl]methyl}phenyl)boronic acid and 2-isopropyl-1H-imidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394830B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-f0774daaab8646e985deab1eda6786df |
| Source note | uspto-grants-2013_03 |