Methyl bromoacetate → HCID 67458831, compound

HRID 1944345Notes

Reaction equation

[CH3:1][C:2]([CH3:27])([CH3:26])[C:3]([C:5]1[CH:25]=[CH:24][C:8]([CH2:9][C:10]2[C:11](=[O:23])[NH:12][C:13]3[C:18]([C:19]=2[CH3:20])=[C:17]([OH:21])[CH:16]=[CH:15][C:14]=3[F:22])=[CH:7][CH:6]=1)=[O:4].[CH3:28][O:29][C:30](=[O:33])[CH2:31]Br>>[CH3:28][O:29][C:30](=[O:33])[CH2:31][O:21][C:17]1[CH:16]=[CH:15][C:14]([F:22])=[C:13]2[C:18]=1[C:19]([CH3:20])=[C:10]([CH2:9][C:8]1[CH:7]=[CH:6][C:5]([C:3](=[O:4])[C:2]([CH3:27])([CH3:26])[CH3:1])=[CH:25][CH:24]=1)[C:11](=[O:23])[NH:12]2

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 67457704HCID 67457704, compound

Product 1

HCID 67458831HCID 67458831, compound

Procedure

The title compound was prepared by the method of Preparation 7a using 3-[4-(2,2-dimethylpropionyl)benzyl]-8-fluoro-5-hydroxy-4-methyl-1H-quinolin-2-one and bromoacetic acid methyl ester.

Sources & evidence

ORD record: ord-4c8e76bcbbc046f29b505f1bfc6c6f06
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394830B2

Reaction notes

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