HCID 67044881, compound → HCID 86652183, compound

HRID 1944392Notes

Reaction equation

HRID 1944392 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH3:20])[S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH2:18][OH:19])(=[O:11])=[O:10])=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH3:20])[S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH:18]=[O:19])(=[O:10])=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 67044881HCID 67044881, compound

Product 1

HCID 86652183HCID 86652183, compoundYield 66.2%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
60 °C

Procedure

A solution of N-(4-fluorophenyl)-2-hydroxymethyl-N-methylbenzenesulfonamide (0.35 g) in chloroform (20 mL) was treated with manganese dioxide (1.2 g), and the resulting mixture was stirred at 60° C. for 16 hours. The mixture was filtered through Celite and the filtrate concentrated under reduced pressure to afford the title compound as colourless oil (0.23 g).

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-f5edb48802e94d7ebbac2029e66ee876
Source dataset
uspto-grants-2013_03
Patent number
US08394836B2

Reaction notes

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