Methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetate → {5-Fluoro-3-[3-(4-fluorobenzenesulfonyl)pyridin-2-ylmethyl]-2-methylindol-1-yl}acetic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[CH:7]=[C:6]1[CH3:15].[F:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([C:27]2[C:28]([CH:33]=O)=[N:29][CH:30]=[CH:31][CH:32]=2)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[CH3:1][O:2][C:3](=[O:16])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[C:7]([CH2:33][C:28]2[C:27]([S:24]([C:21]3[CH:20]=[CH:19][C:18]([F:17])=[CH:23][CH:22]=3)(=[O:25])=[O:26])=[CH:32][CH:31]=[CH:30][N:29]=2)=[C:6]1[CH3:15]Participants
3
Procedure
The title compound was prepared by the method of Preparation 1c using (5-fluoro-2-methylindol-1-yl)acetic acid methyl ester and 3-(4-fluorobenzenesulfonyl)pyridine-2-carbaldehyde.
Sources & evidence
- ORD record
- ord-8cc71d95efa847b5b11caf2047b8b095
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08394836B2
Reaction notes
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