Methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetate → [3-(5-Benzenesulfonylthiazol-4-ylmethyl)-5-fluoro-2-methylindol-1-yl]acetic acid methyl ester

HRID 1944468Notes

Reaction equation

HRID 1944468 reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[CH:7]=[C:6]1[CH3:15].[C:17]1([S:23]([C:26]2[S:30][CH:29]=[N:28][C:27]=2[CH:31]=O)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>ClCCl>[CH3:1][O:2][C:3](=[O:16])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[C:7]([CH2:31][C:27]2[N:28]=[CH:29][S:30][C:26]=2[S:23]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)(=[O:24])=[O:25])=[C:6]1[CH3:15]

Participants

4

Reactant 2

HCID 58247161Methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetateHCID 866522015-(Phenylsulfonyl)-4-thiazolecarboxaldehyde

Product 1

HCID 67045020[3-(5-Benzenesulfonylthiazol-4-ylmethyl)-5-fluoro-2-methylindol-1-yl]acetic acid methyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by the method of Preparation 1c using (5-fluoro-2-methylindol-1-yl)acetic acid methyl ester and 5-benzenesulfonylthiazole-4-carbaldehyde in dichloromethane.

Sources & evidence

ORD record
ord-e86bb7b420e54aab99e490c482271d76
Source dataset
uspto-grants-2013_03
Patent number
US08394836B2

Reaction notes

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