Methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetate → {3-[5-Chloro-3-(pyridine-2-sulfonyl)thiophen-2-ylmethyl]-5-fluoro-2-methylindol-1-yl}acetic acid methyl ester
Reaction equation
[Cl:1][C:2]1[S:6][C:5]([CH:7]=O)=[C:4]([S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)(=[O:11])=[O:10])[CH:3]=1.[CH3:18][O:19][C:20](=[O:33])[CH2:21][N:22]1[C:30]2[C:25](=[CH:26][C:27]([F:31])=[CH:28][CH:29]=2)[CH:24]=[C:23]1[CH3:32]>>[CH3:18][O:19][C:20](=[O:33])[CH2:21][N:22]1[C:30]2[C:25](=[CH:26][C:27]([F:31])=[CH:28][CH:29]=2)[C:24]([CH2:7][C:5]2[S:6][C:2]([Cl:1])=[CH:3][C:4]=2[S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)(=[O:11])=[O:10])=[C:23]1[CH3:32]Participants
3
Procedure
The title compound was prepared by the method of Preparation 42b using 5-chloro-3-(pyridine-2-sulfonyl)thiophene-2-carbaldehyde and (5-fluoro-2-methylindol-1-yl)acetic acid methyl ester.
Sources & evidence
- ORD record
- ord-746249130ace4839a33d76dcc61e27aa
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08394836B2
Reaction notes
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