Methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetate → [3-(3-Benzenesulfonyl-5-chlorothiophen-2-ylmethyl)-5-fluoro-2-methylindol-1-yl]acetic acid methyl ester
Reaction equation
[C:1]1([S:7]([C:10]2[CH:14]=[C:13]([Cl:15])[S:12][C:11]=2[CH:16]=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][O:19][C:20](=[O:33])[CH2:21][N:22]1[C:30]2[C:25](=[CH:26][C:27]([F:31])=[CH:28][CH:29]=2)[CH:24]=[C:23]1[CH3:32]>>[CH3:18][O:19][C:20](=[O:33])[CH2:21][N:22]1[C:30]2[C:25](=[CH:26][C:27]([F:31])=[CH:28][CH:29]=2)[C:24]([CH2:16][C:11]2[S:12][C:13]([Cl:15])=[CH:14][C:10]=2[S:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)(=[O:8])=[O:9])=[C:23]1[CH3:32]Participants
3
Procedure
The title compound was prepared by the method of Preparation 42b using 3-benzenesulfonyl-5-chlorothiophene-2-carbaldehyde and (5-fluoro-2-methylindol-1-yl)acetic acid methyl ester.
Sources & evidence
- ORD record
- ord-36ac6881062c44a1abe842fabd590832
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08394836B2
Reaction notes
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