4-Amino-2-chlorobenzoic acid → HCID 86594440, compound

HRID 1944516Notes

Reaction equation

HRID 1944516 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([Cl:11])[CH:3]=1.[C:12]([O:16]NC1C=CC(C(O)=O)=CC=1C)([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][NH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([Cl:11])[CH:3]=1)([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 171544-Amino-2-chlorobenzoic acidHCID 86594439HCID 86594439, compound

Product 1

HCID 86594440HCID 86594440, compoundYield 79%

Procedure

4-amino-2-chloro-benzoic acid was converted to product in 79% yield, using the procedure described for the synthesis of 4-tert-Butoxyamino-3-methyl-benzoic acid. 1H NMR (DMSO-d6): δ 1.49 (s, 9 H), 7.46 (d of d, 1 H), 7.71 (br s, 1 H), 7.80 (d, 1 H), 9.87 (s, 1 H) and 13.00 (br s, 1 H).

Sources & evidence

ORD record
ord-b8b94d1023304f77ba3c492b5f4331e8
Source dataset
uspto-grants-2013_03
Patent number
US08394828B2

Reaction notes

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