1H-Indazole → HCID 58506951, compound

HRID 1944556Notes

Reaction equation

HRID 1944556 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.Br[CH:11]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:12]([OH:14])=[O:13]>O>[N:1]1[N:2]([CH:11]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:12]([OH:14])=[O:13])[CH:3]=[C:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 92211H-IndazoleHCID 1426812-Bromo-4-methylpentanoic acid

Product 1

HCID 58506951HCID 58506951, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
160 °C

Procedure

Referring to Scheme 1, a mixture of indazole (450 mg, 3.86 mmol) and 2-bromo-4-methylpentanoic acid (1.5 eq.) was heated to 160° C. for 4 hours. The mixture was cooled, diluted with water, extracted by EtOAc, and dried over MgSO4. The solvent was then removed to give the crude product, which was used for the next step without further purification. [M+H] calc'd for C14H16N2O4, 233; found, 233.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted by EtOAc
  3. dry with materialdried over MgSO4
  4. customThe solvent was then removed

Sources & evidence

ORD record
ord-a620619841274d17985ea4fdafe0a5a4
Source dataset
uspto-grants-2013_03
Patent number
US08394843B2

Reaction notes

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