Isopropanol → 2-methyl-3,7-diphenyl-3H-imidazo[4,5-b]pyridine

HRID 19446Notes

Reaction equation

HRID 19446 reaction equation
[C:1]1([NH:7][C:8]2[C:13]([NH2:14])=[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:11]=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:21](O)(C)[CH3:22]>>[CH3:21][C:22]1[N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]2=[N:9][CH:10]=[CH:11][C:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)=[C:13]2[N:14]=1

Participants

3

Reactant 2

HCID 3776IsopropanolHCID 59346194N2,4-diphenylpyridine-2,3-diamine

Product 1

HCID 685610972-methyl-3,7-diphenyl-3H-imidazo[4,5-b]pyridineYield 74%

Procedure

0.70 mol of N2,4-diphenylpyridine-2,3-diamine and 2.56 mol of ethoxy ethylene malononitrile was added in 10 ml of isopropanol, and refluxed for 6 hours. The solution was removed and was purified by using column chromatography to thereby produce a solid crystalline product at a yield of 74%.

Workup

  1. temperaturerefluxed for 6 hours
  2. customThe solution was removed
  3. customwas purified
  4. customto thereby produce a solid crystalline product at a yield of 74%

Sources & evidence

ORD record
ord-f09f249ed8f34931a4f2c2f72625a639
Source dataset
uspto-grants-2010_06
Patent number
US07745020B2

Reaction notes

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