HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 6-Aminomethyl-2-(4-cyclopropylpiperazin-1-yl)benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-(4-Cyclopropylpiperazin-1-yl)benzothiazole-6-carbonitrile | HCID 59588789 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 6-Aminomethyl-2-(4-cyclopropylpiperazin-1-yl)benzothiazole | HCID 59588783 | 49.3% |
Reaction Steps
To a solution of 2-(4-cyclopropylpiperazin-1-yl)benzothiazole-6-carbonitrile (1 g, 3.52 mmol) in MeOH-THF (120 mL, 5:3) was added NH4OH (15 mL) and Raney Ni (200 mg). The mixture was stirred for 12 h at rt under 50 psi H2 atmosphere. After filtration, the mixture was concentrated to give 6-aminomethyl-2-(4-cyclopropylpiperazin-1-yl)benzothiazole (500 mg, 49.3%), which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394842B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-a3d912f2a3f246dea457e5926ed550d5 |
| Source note | uspto-grants-2013_03 |