反应详情

To a solution of 2-(4-cyclopropylpiperazin-1-yl)benzothiazole-6-carbonitrile (1 g, 3.52 mmol) in MeOH-THF (120 mL, 5:3) was added NH4OH (15 mL) and Raney Ni (200 mg). The mixture was stirred for 12 h at rt under 50 psi H2 atmosphere. After filtration, the mixture was concentrated to give 6-aminomethyl-2-(4-cyclopropylpiperazin-1-yl)benzothiazole (500 mg, 49.3%), which was used in the next step without further purification.

1. filtrationAfter filtration
2. concentrationthe mixture was concentrated